Publications:
Malnutrition, Frailty, and Sarcopenia in Patients With Cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases.
Lai JC, Tandon P, Bernal W, Tapper EB, Ekong U, Dasarathy S, Carey EJ.
Hepatology. 2021 Sep;74(3):1611-1644. doi: 10.1002/hep.32049.
PMID: 34233031
The relationship between frailty and cirrhosis etiology: From the Functional Assessment in Liver Transplantation (FrAILT) Study.
Xu CQ, Mohamad Y, Kappus MR, Boyarsky B, Ganger DR, Volk ML, Rahimi RS, Duarte-Rojo A, McAdams-DeMarco M, Segev DL, Ladner DP, Verna EC, Grab J, Tincopa M, Dunn MA, Lai JC.
Liver Int. 2021 Oct;41(10):2467-2473. doi: 10.1111/liv.15006. Epub 2021 Jul 14.
PMID: 34219362
Assessment of the Frail Patient With End-Stage Liver Disease: A Practical Overview of Sarcopenia, Physical Function, and Disability.
Williams FR, Milliken D, Lai JC, Armstrong MJ.
Hepatol Commun. 2021 Feb 26;5(6):923-937. doi: 10.1002/hep4.1688. eCollection 2021 Jun.
PMID: 34141980
Sarcopenia and frailty in decompensated cirrhosis.
Tandon P, Montano-Loza AJ, Lai JC, Dasarathy S, Merli M.
J Hepatol. 2021 Jul;75 Suppl 1(Suppl 1):S147-S162. doi: 10.1016/j.jhep.2021.01.025.
PMID: 34039486
Inpatient Frailty Assessment Is Feasible and Predicts Nonhome Discharge and Mortality in Decompensated Cirrhosis.
Serper M, Tao SY, Kent DS, Garren P, Burdzy AE, Lai JC, Gougol A, Bloomer PM, Reddy KR, Dunn MA, Duarte-Rojo A.
Liver Transpl. 2021 Dec;27(12):1711-1722. doi: 10.1002/lt.26100. Epub 2021 Aug 1.
PMID: 34018303
A Multicenter Pilot Randomized Clinical Trial of a Home-Based Exercise Program for Patients With Cirrhosis: The Strength Training Intervention (STRIVE).
Lai JC, Dodge JL, Kappus MR, Wong R, Mohamad Y, Segev DL, McAdams-DeMarco M.
Am J Gastroenterol. 2021 Apr;116(4):717-722. doi: 10.14309/ajg.0000000000001113.
PMID: 33982941
Frailty is strongly associated with self-reported symptom burden among patients with cirrhosis.
Deng LX, Bischoff KE, Kent DS, O'Riordan DL, Pantilat SZ, Lai JC.
Eur J Gastroenterol Hepatol. 2021 Dec 1;33(1S Suppl 1):e395-e400. doi: 10.1097/MEG.0000000000002113.
PMID: 33731588
Evaluating the Associations Between the Liver Frailty Index and Karnofsky Performance Status With Waitlist Mortality.
Xu CQ, Yao F, Mohamad Y, Wong R, Kent D, Seetharaman S, Srisengfa Y, Lai JC.
Transplant Direct. 2021 Jan 7;7(2):e651. doi: 10.1097/TXD.0000000000001097. eCollection 2021 Feb.
PMID: 33437866
Association of Frailty and Sex With Wait List Mortality in Liver Transplant Candidates in the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study.
Lai JC, Ganger DR, Volk ML, Dodge JL, Dunn MA, Duarte-Rojo A, Kappus MR, Rahimi RS, Ladner DP, Boyarsky B, McAdams-DeMarco M, Segev DL, McCulloch CE, Verna EC.
JAMA Surg. 2021 Mar 1;156(3):256-262. doi: 10.1001/jamasurg.2020.5674.
PMID: 33377947
Frailty and Risk of Serious Infections in Biologic-treated Patients With Inflammatory Bowel Diseases.
Singh S, Heien HC, Sangaralingham L, Shah ND, Lai JC, Sandborn WJ, Moore AA.
Inflamm Bowel Dis. 2021 Oct 18;27(10):1626-1633. doi: 10.1093/ibd/izaa327.
PMID: 33325507
Frailty as an Immune-Mediated Condition That Leads to an Increased Risk of Acute Cellular Rejection in Liver Transplant Recipients.
Fozouni L, Lai JC.
Clin Liver Dis (Hoboken). 2020 Jun 30;15(6):243-245. doi: 10.1002/cld.960. eCollection 2020 Jun.
PMID: 32617158
Psychological contributors to the frail phenotype: The association between resilience and frailty in patients with cirrhosis.
Wong RJ, Mohamad Y, Srisengfa YT, Kent DS, Seetharaman S, Shah RJ, Lai JC.
Am J Transplant. 2021 Jan;21(1):241-246. doi: 10.1111/ajt.16131. Epub 2020 Jul 21.
PMID: 32524691
Identifying an Optimal Liver Frailty Index Cutoff to Predict Waitlist Mortality in Liver Transplant Candidates.
Kardashian A, Ge J, McCulloch CE, Kappus MR, Dunn MA, Duarte-Rojo A, Volk ML, Rahimi RS, Verna EC, Ganger DR, Ladner D, Dodge JL, Boyarsky B, McAdams-DeMarco M, Segev DL, Lai JC.
Hepatology. 2021 Mar;73(3):1132-1139. doi: 10.1002/hep.31406. Epub 2020 Oct 30.
PMID: 32491208
Changes in frailty are associated with waitlist mortality in patients with cirrhosis.
CE, Haugen CE, McAdams-DeMarco M, Ladner DP, Segev DL, Verna EC; Multi-Center Functional Assessment in Liver Transplantation (FrAILT) Study.
J Hepatol. 2020 Sep;73(3):575-581. doi: 10.1016/j.jhep.2020.03.029. Epub 2020 Mar 30.
PMID: 32240717
Physical Function, Physical Activity, and Quality of Life After Liver Transplantation.
Dunn MA, Rogal SS, Duarte-Rojo A, Lai JC.
Liver Transpl. 2020 May;26(5):702-708. doi: 10.1002/lt.25742.
PMID: 32128971
Frailty and the Burden of Concurrent and Incident Disability in Patients With Cirrhosis: A Prospective Cohort Study.
Lai JC, Dodge JL, McCulloch CE, Covinsky KE, Singer JP.
Hepatol Commun. 2019 Oct 31;4(1):126-133. doi: 10.1002/hep4.1444. eCollection 2020 Jan.
PMID: 31909360
Sex Differences in the Association Between Frailty and Sarcopenia in Patients With Cirrhosis.
Fozouni L, Wang CW, Lai JC.
Clin Transl Gastroenterol. 2019 Dec;10(12):e00102. doi: 10.14309/ctg.0000000000000102.
PMID: 31789932
Frailty Is Associated With Increased Rates of Acute Cellular Rejection Within 3 Months After Liver Transplantation.
Fozouni L, Mohamad Y, Lebsack A, Freise C, Stock P, Lai JC.
Liver Transpl. 2020 Mar;26(3):390-396. doi: 10.1002/lt.25669. Epub 2020 Feb 3.
PMID: 31655014
Association Between Liver Transplant Wait-list Mortality and Frailty Based on Body Mass Index.
Haugen CE, McAdams-DeMarco M, Verna EC, Rahimi RS, Kappus MR, Dunn MA, Volk ML, Gurakar A, Duarte-Rojo A, Ganger DR, O'Leary JG, Ladner D, Garonzik-Wang J, Segev DL, Lai JC.
JAMA Surg. 2019 Dec 1;154(12):1103-1109. doi: 10.1001/jamasurg.2019.2845.
PMID: 31509169
Review article: impact of exercise on physical frailty in patients with chronic liver disease.
Williams FR, Berzigotti A, Lord JM, Lai JC, Armstrong MJ.
Aliment Pharmacol Ther. 2019 Nov;50(9):988-1000. doi: 10.1111/apt.15491. Epub 2019 Sep 9.
PMID: 31502264
Use of Functional Assessment to Define Therapeutic Goals and Treatment.
High KP, Zieman S, Gurwitz J, Hill C, Lai J, Robinson T, Schonberg M, Whitson H.
J Am Geriatr Soc. 2019 Sep;67(9):1782-1790. doi: 10.1111/jgs.15975. Epub 2019 May 13.
PMID: 31081938
Frailty in liver transplantation: An expert opinion statement from the American Society of Transplantation Liver and Intestinal Community of Practice.
Lai JC, Sonnenday CJ, Tapper EB, Duarte-Rojo A, Dunn MA, Bernal W, Carey EJ, Dasarathy S, Kamath BM, Kappus MR, Montano-Loza AJ, Nagai S, Tandon P.
Am J Transplant. 2019 Jul;19(7):1896-1906. doi: 10.1111/ajt.15392. Epub 2019 May 8.
PMID: 30980701
The Range and Reproducibility of the Liver Frailty Index.
Wang CW, Lebsack A, Chau S, Lai JC.
Liver Transpl. 2019 Jun;25(6):841-847. doi: 10.1002/lt.25449. Epub 2019 Apr 29.
PMID: 30884128.
Multicenter Study of Age, Frailty, and Waitlist Mortality Among Liver Transplant Candidates.
Haugen CE, McAdams-DeMarco M, Holscher CM, Ying H, Gurakar AO, Garonzik-Wang J, Cameron AM, Segev DL, Lai JC.
Ann Surg. 2020 Jun;271(6):1132-1136. doi: 10.1097/SLA.0000000000003207.
PMID: 30672803
Frailty Associated With Waitlist Mortality Independent of Ascites and Hepatic Encephalopathy in a Multicenter Study.
Lai JC, Rahimi RS, Verna EC, Kappus MR, Dunn MA, McAdams-DeMarco M, Haugen CE, Volk ML, Duarte-Rojo A, Ganger DR, O'Leary JG, Dodge JL, Ladner D, Segev DL.
Gastroenterology. 2019 May;156(6):1675-1682. doi: 10.1053/j.gastro.2019.01.028. Epub 2019 Jan 19.
PMID: 30668935
Report from the American Society of Transplantation on frailty in solid organ transplantation.
Kobashigawa J, Dadhania D, Bhorade S, Adey D, Berger J, Bhat G, Budev M, Duarte-Rojo A, Dunn M, Hall S, Harhay MN, Johansen KL, Joseph S, Kennedy CC, Kransdorf E, Lentine KL, Lynch RJ, McAdams-DeMarco M, Nagai S, Olymbios M, Patel J, Pinney S, Schaenman J, Segev DL, Shah P, Singer LG, Singer JP, Sonnenday C, Tandon P, Tapper E, Tullius SG, Wilson M, Zamora M, Lai JC.
Am J Transplant. 2019 Apr;19(4):984-994. doi: 10.1111/ajt.15198. Epub 2018 Dec 22.
PMID: 30506632
Beta-blockers and physical frailty in patients with end-stage liver disease.
Kuo SZ, Lizaola B, Hayssen H, Lai JC.
World J Gastroenterol. 2018 Sep 7;24(33):3770-3775. doi: 10.3748/wjg.v24.i33.3770.
PMID: 30197482
How I Approach It: Improving Nutritional Status in Patients With Cirrhosis.
Lai JC, Tandon P.
Am J Gastroenterol. 2018 Nov;113(11):1574-1576. doi: 10.1038/s41395-018-0080-1.
PMID: 29867180
Acute-on-Chronic Liver Failure: Getting Ready for Prime Time?
Bajaj JS, Moreau R, Kamath PS, Vargas HE, Arroyo V, Reddy KR, Szabo G, Tandon P, Olson J, Karvellas C, Gustot T, Lai JC, Wong F.
Hepatology. 2018 Oct;68(4):1621-1632. doi: 10.1002/hep.30056. Epub 2018 Sep 22.
PMID: 29689120
Physical frailty after liver transplantation.
Lai JC, Segev DL, McCulloch CE, Covinsky KE, Dodge JL, Feng S.
Am J Transplant. 2018 Aug;18(8):1986-1994. doi: 10.1111/ajt.14675. Epub 2018 Mar 13.
PMID: 29380529
The Liver Frailty Index Improves Mortality Prediction of the Subjective Clinician Assessment in Patients With Cirrhosis.
Lai JC, Covinsky KE, McCulloch CE, Feng S.
Am J Gastroenterol. 2018 Feb;113(2):235-242. doi: 10.1038/ajg.2017.443. Epub 2017 Dec 12.
PMID: 29231189
Association of Cardiac Abnormalities to the Frail Phenotype in Cirrhotic Patients on the Waitlist: From the Functional Assessment in Liver Transplantation Study.
Puchades L, Chau S, Dodson JA, Mohamad Y, Mustain R, Lebsack A, Aguilera V, Prieto M, Lai JC.
Transplantation. 2018 Mar;102(3):e101-e107. doi: 10.1097/TP.0000000000002025.
PMID: 29189486
Development of a novel frailty index to predict mortality in patients with end-stage liver disease.
Lai JC, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, Feng S.
Hepatology. 2017 Aug;66(2):564-574. doi: 10.1002/hep.29219. Epub 2017 Jun 28.
PMID: 28422306
Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist.
Sinclair M, Poltavskiy E, Dodge JL, Lai JC.
World J Gastroenterol. 2017 Feb 7;23(5):899-905. doi: 10.3748/wjg.v23.i5.899.
PMID: 28223735
Editorial: Advancing Adoption of Frailty to Improve the Care of Patients with Cirrhosis: Time for a Consensus on a Frailty Index.
Lai JC.
Am J Gastroenterol. 2016 Dec;111(12):1776-1777. doi: 10.1038/ajg.2016.485.
PMID: 27924103
Performance-Based Measures Associate With Frailty in Patients With End-Stage Liver Disease.
Lai JC, Volk ML, Strasburg D, Alexander N.
Transplantation. 2016 Dec;100(12):2656-2660. doi: 10.1097/TP.0000000000001433.
PMID: 27495749
Defining the threshold for too sick for transplant.
Lai JC.
Curr Opin Organ Transplant. 2016 Apr;21(2):127-32. doi: 10.1097/MOT.0000000000000286.
PMID: 26825359